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Document Type |
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Thesis |
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Document Title |
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Chemical Examination of The Constituents of Some Wild Medicinal Plants From Tabuk Area الفحص الكيميائي لمكونات بعض النباتات الطبية البرية بمنطقة تبوك |
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Document Language |
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Arabic |
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Abstract |
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The work described in this Thesis has been undertaken with the object of contributing further studies of some medicinal plants wild in Tabuk area in Kingdom of Saudi Arabia. Some plants were chosen according their valuable medicinal importance and many of them used as edible plants.
The volatile oils from the fourteen plant samples from different families were isolated by hydrodistillation. The isolated and identification of 171 volatile oils constituents were carried out by GC/MS analysis.
Three plants (Ducrosia anethifolia, Artemisia judaica L., Chrysanthemum coranorium) were selected for further phytochemical examinations.
From the ethyl acetate extract of Ducrosia anethifolia, Aviprin MD1 was isolated and three furocoumarins (Isooxypeucedanin MD3, Pabulenol MD4, Oxypeucedanin methanolate MD5) were isolated from methanolic extract beside one sterol was isolated and identified as β-sitosterol-3-O-glucoside.
One Eudesmane sesquiterpene vulgarin MA1 and a flavone aglycone Cirsimaritin MA4 beside one sugar unit Pinitol MA3 were isolated from ethyl acetate extract of Artemisia judaica L. On the other hand, methanolic extract gave two flavone aglycones (Chrysoeriol MA5, Apigenin MA6) and stigmasterol-3-O-glucoside.
From the ethyl acetate of the third plant Chrsanthemum coranorium two flavone aglycones (Santin MC1, Cirsimaritin MC2) were isolated and from methanolic extract four flavonoid glycosides were isolated and identified as
(Apigenin-7-O-[2''(6'''-O-β-D-acetylglucopyranosyl)]-6''-O-acetylglucopyranoside and
Apigenin-7-O-[2''(6'''-O-β-D-acetylgalactopyranosyl)]-6''-O-acetylglucopyranoside) MC3
Apigenin-7-O-(2''-O-β-D-glucopyranosyl)-β-D-glucopyranoside MC4
6- Methoxy quercetin-7-O-β-D-glucopyranoside MC5
This compounds did not isolate from chrysanthemum before.
The structures of all the isolated compounds were fully established by spectroscopic methods (UV, MS, 1H, 13C NMR).
Sterols, hydrocarbons and fatty acids components were identified in petroleum ether of the three plants by GLC analysis
Finally the volatile oils of the nine samples were tested for their antiumor activity.
Furthermore furocoumarins isolated from ethyl acetate of Ducrosia anethifolia showed improvement in liver function, while it did not show improvement in kidney function, as well as enzyme AST, which may indicate adverse impact on the heart. The results also showed improvement in the level of TC and LDL in groups MD4, MDExt, MDaq. |
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Supervisor |
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Nagwa M. Shalaby |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Number Of Pages |
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264 |
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Added Date |
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Wednesday, March 19, 2014 |
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Researchers
| مرزوقة عزيز البلوي | Albalawy, Marzoukah Aziz | Investigator | Doctorate | |
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