Document Details
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Document Type |
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Thesis |
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Document Title |
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Biochemical Study on The Influence of Parsley, Thyme, Rosemary and It's Active Compounds on Bronchial Asthma. دراسة كيمو حيوية حول تأثير كلٍ من البقدونس والزعتر وحصى اللبان ومركباتها الفعالة على حالة الربو الشعبي. |
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Subject |
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Asthma |
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Document Language |
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Arabic |
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Abstract |
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Saudi Arabia experienced rapid growth and development, accompanied by an increase in population and an expansion in cultural activities. The industrial expansion has caused an increase in external contamination from factories transportation and extensive building constructions as well as weather. The use of heating and air conditioning systems, cleaning materials, chemicals and smoking consequently resulted in internal sources of pollution. It has been confirmed that there is a close relationship between high levels of pollutants (such as oxidizing substances in the internal and external environment) and the high rates of allergies and respiratory diseases. Asthma is very common in Saudi Arabia and my affect the lungs. It is characterized by sporadic occurrence of bridge or in part of the bronchioles caused by inflammation and swelling of the inner lining with an increase in the secretion of sticky mucus, cough and muscle contraction of the chest. Under normal circumstances, the defense system of the body has the balance between the production of oxidizing substances and antioxidant. However, under increased exposure to oxidizing materials the body is unable to cope and this results in
a condition called Vintage (oxidative stress) causing many aliment including asthma.
This study was designed to investigate the indicators of the asthma disease in the Qassim region. Blood samples from asthma patients in the hospital were obtained. The main aim of the study was to of estimate the quantities of the two oxidants, hydrogen peroxide and nitric oxide radical. The study included estimation of two antioxidant enzymes, superoxide dismutase and glutathione peroxidase. In addition the concentration of lipid peroxidation products of binary malondialdehyde and
8-isoprostaglandin F2α were also investigated. Total protein, carbonyl protein and hemoglobin level were also assessed. The study also focused on the effects of three naturally occurring active compounds from these plants in rats that developed asthma upon interaction . The three plants used were parsley, Thyme and rosemary and the active compounds were ascorbic acid, thymol, rosmarinic acid. After the intended of duration of treatment, blood samples were collected. The results of the biochemical indicators obtained from asthma patients were compared the results of a diseased rats subjected to different treatments.
The results showed that samples of asthma patients had high rates of oxidative stress, accompanied by a major imbalance in the amount of antioxidants. In addition, high rates of lipid peroxidation products and carbonyl protein, was also associated with a reduction in the rates of total protein and blood content of hemoglobin. The results also showed groups of rats treated with plants and active compounds showed a significant improvement in the rates of antioxidant enzyme, total proteins and hemoglobin. It was accompanied by apparent decline in the rates of free radicals and oxidative agent, carbonyl protein and lipid peroxidation products compared to the control groups.
In summary, this study was aimed investigate the role of oxidative agent and important antioxidants indicators that are involved in asthmatic condition. The study also indicates that the plants and it's active compounds increased the rates of antioxidants in the body, and the ability to get rid of oxidative agent and free radicals that are generated inside the body, or due pollution environment.
Hence, this study confirms the potential these plants and it's active compounds as possible means to treat asthma. However, further detailed studies are need to investigate the role of these plants in treating the asthma and related sicknesses. We also suggest that further studies are also need in to identify, characteristics and purity active compounds from medicinal plants and herbs to be used as alternative therapy with minimum side effects. |
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Supervisor |
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Dr. Nadia Amine Abdul majed |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Number Of Pages |
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296 |
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Added Date |
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Tuesday, September 3, 2013 |
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Researchers
| مها إبراهيم الخلف | AL-KHALAF, MAHA IBRAHIM | Investigator | Doctorate | |
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