Document Details

Document Type : Thesis 
Document Title :
The optimal formulation of icariin in the form of a microemulsion and the evaluation of its efficacy to protect the heart from toxicity caused by the administration of doxorubicin in a rat model.
عمل الصيغة المثالية لدواء الآيكارين بصورة مستحلب متناهي الصغر وتقيم مدى فاعليته لحماية القلب من السمية الناجمة عن تعاطي دواء الدوكسوروبيسين في نموذج الجرذان.
 
Subject : faculty of Pharmacy 
Document Language : Arabic 
Abstract : Icariin (ICR) is a flavonoid found in plants and possesses cardioprotective, hepatoprotective, anticancer, and anti-inflammatory properties. Even though icariin has been reported to exhibit therapeutic promise in various preclinical and clinical studies, its widespread clinical utility is limited because of low aqueous solubility and low absorption following oral administration. Thus, an enhanced drug delivery system is required to improve therapeutic efficacy and clinical outcomes. Hence, this research aimed to develop and explore icariin nano-emulsions (ICR-NE) for improved cardioprotective action against doxorubicin (Dox)-induced cardiotoxicity. Critical formulation variables, such as globule size and zeta potential of ICR-NE, were studied using a Box–Behnken response surface design. The improved formulation’s globule size and zeta potential were found to be 110.7 nm and −18.45 mV, respectively. Almost 100% transmittance confirmed the minimum nano-size of ICR-NE. Further, thermodynamic stability study showed absence of cracking and phase separation in ICR-NE. Viscosity studies have reported adequate consistency for oral administration. Additionally, an in vitro drug release study showed a sustained release pattern for ICR-NE. The ICR-NE led to significant (p < 0.01) restoration of both serum cardiac and anti-inflammatory markers and cardiac tissue antioxidants compared to the free ICR and Dox-treated groups. As compared to the free ICR and Dox-treated groups, pre-treatment with ICR-NE caused a reduction in the expression of Bax and caspase-3, and hence, mitigated apoptosis-induced cardiotoxicity. Moreover, pretreatment with ICR-NE caused a significant reduction in the heart weight/body weight ratio of histological and fibrotic aberrations toward normal. In conclusion, the current study showed that ICR-NE exhibits a superior cardioprotective effect, possibly due to improved solubility and antioxidant, anti-inflammatory, and anti-apoptotic activities. 
Supervisor : Dr. Shadab Aki 
Thesis Type : Master Thesis 
Publishing Year : 1444 AH
2022 AD 
Added Date : Monday, February 27, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هتون عبد الرحمن محروسMahrous, Hatoon AbdulrahmanResearcherMaster 

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