Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
POTENTIAL ANTIEPILEPTIC ACTIVITY AND HEPATOPROTECTIVE EFFECTS OF ASTAXANTHIN IN EPILEPTIC RATS TREATED WITH VALPROIC ACID. تأثيرمادة الأستازانثين على الصرع و إصابات الكبد في الجرذان المصابة بالصرع والمعالجة بحمض الفالبرويك |
|
Subject |
: |
Faculty of medicine |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Background: Epilepsy is a neurological disease characterized by sudden, abnormal,
and hyper-synchronization discharges form a bunch of neurons in the central nervous
system. Valproic acid (VPA) is commonly used broad spectrum with antiepileptic
effect. However, in many cases, patients develop resistance to VPA treatment and also
has been linked to drug-induced liver injuries. Oxidative stress (OS) might be a major
catalyst for disease progression and hepatotoxicity. Therefore, antioxidants, as
Astaxanthin (ASTA), thought to have a potential to become therapeutic agents through
counteracting of reactive oxygen species-mediated damage.
Aim: To evaluate the potential antiepileptic and hepatoprotective effect of ASTA in
pentylenetetrazol (PTZ) epileptic model rats chronically treated with VPA.
Method: Fifty-male Wistar rats were randomly divided into five groups: Non-PTZ
group (negative control), PTZ (positive control), PTZ/VPA, PTZ/ASTA, and
PTZ/VPA/ASTA treated groups and used to assess the tested drugs on the course of
PTZ kindling, motor coordination, biochemical and histopathological changes.
Results: PTZ/VPA group showed neuroprotective effect with improvement in
antioxidant, motor coordination test, uric acid, cytochrome P-450 2E1, liver enzymes,
and histopathological changes induced by PTZ. Also, VPA exhibited some antiinflammatory effect as a result of reduction in tumor necrosis factor- α (TNF-α).
However, there were some pro-oxidative effect in hepatic tissue. Astaxanthin exhibited
anticonvulsant effect and more anti-inflammatory and antioxidant effects than VPA
treated group. In combined therapy, ASTA enhanced VPA antiepileptic effect through
a great reduction in oxidative stress, tumor necrosis factor-α, glutamate, and much
increase in reduced glutathione level. Also, there were a great improvement in motor
coordination and histopathological changes as compared to VPA group.
Conclusion: ASTA has antiepileptic and antioxidant effects. Combination of VPA
with ASTA act as an additive effect in antiepileptic activity, reduce oxidant effect, and
hepatotoxic effect of VPA. |
|
Supervisor |
: |
Prof. Hala Salah Abd El-Kawy Eweis |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1441 AH
2020 AD |
|
Co-Supervisor |
: |
Prof. Huda Mohammed Naher AlKreathy |
|
Added Date |
: |
Tuesday, June 23, 2020 |
|
Researchers
| يسرا عطا عبد القادر | Abdulqader, Yussra Ata | Researcher | Master | |
|
Back To Researches Page
|