Document Details

Document Type : Thesis 
Document Title :
STUDY OF CELLULAR SENESCENCE AND VITAMIN D DEFICIENCY IN NON-ALCOHOLIC FATTY LIVER DISEASE AND THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN D SUPPLEMENTATION.
دراسة الشيخوخة الخلوية ونقص فيتامين (د) في مرض الكبد الدهني الغير كحولي والتأثير الوقائي المحتمل لمكملات فيتامين (د)
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background and aim of the work: Non-alcoholic fatty liver disease (NAFLD) is a pathological process triggered by a variety of factors for excessive fatty accumulation with possible involvement of vitamin D deficiency and cellular senescence. The aim of this study is to investigate the pathophysiologic role of vitamin D deficiency and cellular senescence in NAFLD development. Moreover, it aims to investigate the protective role of vitamin D supplementation. Material and Methods: This is an experimental Case/Control study. A total number of 45 male albino rats were enrolled in this study. Animals were divided into 4 groups: Negative and positive control groups. A model of NAFLD and vitamin D treated NAFLD groups. At the end of the experiment, all rats were subjected to the following investigation; Biochemical estimation of serum 25 hydroxycholecalciferol, Senescence marker protein - 30(SMP-30), Lipid profile and calculation of homeostatic model of insulin resistance (HOMA-IR). Histological examination of liver samples was also carried out. Results: NAFLD group shows a significant increase in glucose, insulin levels and HOMA- IR as compared to both normal controls. This finding indicates the intimate association between insulin resistance and NAFLD pathogenesis. Moreover, it was found that NAFLD group shows a significant decrease in SMP-30 level as compared to normal controls. While Vitamin D-treated NAFLD group shows significant increased SMP-30 and decrease in HOMA-IR in comparison to non-treated NAFLD group. Conclusion: Vitamin D deficiency and increased cellular senescence are key features of NAFLD. Vitamin D supplementation could play a protective role which needs further investigation including clinical human study. Key words: NAFLD, vitamin D, cellular senescence, HOMA-IR, SMP-30. 
Supervisor : PROF. AYMAN ZAKY ELSAMANOUDY 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Co-Supervisor : DR. FAYZA FAWAZ ALFAYEZ 
Added Date : Monday, March 2, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حاسن عبد الله الغامديALGHAMDI, HASEN ABDULLAHResearcherMaster 

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