Document Details

Document Type : Thesis 
Document Title :
STUDY OF POTENTIAL GASTROPROTECTIVE EFFECT OF TETRAMETHYLPYRAZINE IN EXPERIMENTAL ANIMALS
دراسة التأثير الواقي المحتمل لمركب رباعي ميثيل بيرازين على المعدة في حيوانات التجارب
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : • Background: At present, available antiulcer medications reveal partial efficacy and numerous adverse reactions. Tetramethylpyrazine (TMP) was clinically used in China for the prevention and treatment of vascular diseases due to its potential antioxidant, anti-inflammatory and angiogenic properties. However, there is a scarcity of information regarding its potential protective effects against gastric ulcers. • Objective: To investigate the potential gastroprotective effect of TMP against indomethacin-induced gastric ulcer in rats as well as the possible underlying mechanisms. • Methods: TMP was tested at 3 doses (15, 30 & 60 mg/kg/d po) three days before indomethacin challenge (25 mg/kg ip). Gastric ulcer was evaluated via morphological and histopathological changes of gastric mucosa and mucous secretion. Oxidative status was assessed by tissue content of GSH, MDA and CAT activity, while TNFα and IL-6 were measured as inflammatory mediators. The protective gastric biomarker PGE2 was investigated in addition to the angiogenic marker vascular endothelial growth factor (VEGF). • Results & Discussion: TMP was effective (at 30 and 60 mg/kg/d) in promoting mucus secretion and preventing histopathologic changes induced by indomethacin. Mechanistically, TMP significantly alleviated indomethacin-induced oxidative injury by enhancing GSH content and CAT activity while reducing lipid peroxidation as expressed by MDA concentration. In addition, TMP effectively ameliorated inflammatory status as evidenced by reducing TNFα and IL-6 concentrations. On the other hand, TMP enhanced the protective mediator PGE2 and encouraged angiogenesis via increasing immunohistochemical expression of VEGF. • Conclusion: TMP possesses a potential protective effect against indomethacin-induced gastric ulcer. This could be explained – at least partly – by its antioxidant, antiinflammatory and angiogenic effects. 
Supervisor : Dr. Ahmed Esmat Amer 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Co-Supervisor : Dr. Huda Alkreathy 
Added Date : Tuesday, February 11, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد خلف الغامديAlghamdi, Mohammed KhalafResearcherMaster 

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