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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Design and Development of Vaginal Insert of Antifungal Drug
تصميم وتطوير عقار مضاد للفطريات على صيغة ادراج مهبلي
Subject
:
faculty of Pharmacy
Document Language
:
Arabic
Abstract
:
Fluconazole, used orally for vaginal candidiasis, has reported gastrointestinal side effects. Therefore, researchers directed towards the drug vaginal delivery. However, vaginal delivery is limited by poor retention and leakage. Thus, this work aimed at exploring chitosan/anion polyelectrolyte complex (PEC) for the formulation of Fluconazole vaginal inserts with controlled release and appreciable mucoadhesion. PECs were prepared and assessed for interactions. Fluconazole PEC based vaginal inserts were prepared by lyophilization using mannitol. 3151 factorial design was applied to investigate the effect of the anion type and CH/anion ratio on the inserts mucoadhesion and release properties. The optimized insert [based on 5:5 CH: anionic polymer (sodium alginate)] release was modulated by the release retardant; Compritol® 888. The selected formulation was subjected to microbiological and histological evaluation. Fluconazole inserts showed satisfactory drug content, acceptable friability percentages and highest swelling indices at six hours. Statistical analysis showed significant effect of the studied factors on detachment force and release properties. Microbiological assays revealed significantly higher antifungal activity of inserts compared to Fluconazole solution. Reduced inflammatory cells were confirmed by histological evaluation. CH/Alg based vaginal insert could be a promising platform for vaginal delivery of antifungal drugs used for vaginal candidiasis treatment. Keywords: Fluconazole; chitosan; alginate; lyophilization; polyelectrolyte complex; vaginal; microbiology; histology.
Supervisor
:
Dr. Hibah Aldawsari
Thesis Type
:
Master Thesis
Publishing Year
:
1440 AH
2019 AD
Co-Supervisor
:
Dr. Shaimaa Mohamed Badr-Eldin
Added Date
:
Sunday, July 14, 2019
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
بيان درويش
Darwesh, Bayan
Researcher
Master
Files
File Name
Type
Description
44709.pdf
pdf
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