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Document Type |
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Thesis |
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Document Title |
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" POTENTIAL PROTECTIVE EFFECT OF ACHILLEA FRAGRANTISSIMA AGAINST INDOMETHACIN INDUCED-GASTRIC ULCER IN MALE RATS " " التأثير الوقائي المحتمل لمُستخلص نبات القيصوم ضد قرحة المعدة المحُدثة بواسطة الاندوميثاسين في ذكور الجرذان " |
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Subject |
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Faculty of Home Economics |
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Document Language |
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Arabic |
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Abstract |
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Gastric ulcer is one of the major gastrointestinal disorders with increasing incidence and prevalence globally. Ulceration is a benign lesion of the mucosal epithelium upon exposure of the stomach to excess acid and aggressive pepsin activity. This study aimed to investigate the impact of the potential protective effect of Achillea Fragrantissima extract (AFE) alone or combined with ranitidine (RAN) on gastric ulcers induced by indomethacin (IND) in the male rats. The study was conducted on forty-two adult male Albino Wister rats, they were divided into six equal groups. Group I: negative control group, group II: AFE (800 mg/kg b.wt/day) orally, group III: IND, group IV: RAN (20 mg/kg b.wt /day), group V: were given AFE, and group VI given AFE combined with RAN. After 14 days, groups IV, V and VI received a single oral dose of IND (25 mg/kg b.wt) to induce peptic ulcer. Oxidative stress markers and biomarkers of gastric ulcer (gross evaluation of gastric lesions, ulcer index, pH and total gastric acidity), as well as, histopathological and histochemical examination of the stomach were also performed. Results revealed that pre-treatment with AFE combined with RAN for 2 weeks significantly decreased the gastric acidity and gastric ulcer index. Oxidative stress markers were significantly improved as compared to the IND group. Histopathological examination of the stomach showed alleviation of histological degeneration changes as well as, histochemical changes caused by IND. These results suggested that, oral administration of AFE could be useful in the management of gastric ulcers. The study recommend that the intake of AFE with RAN treatment may be beneficial for patients suffering from acute gastric ulcer.
Key words: Peptic ulcer, Indomethacin, Achillea Fragrantissima, Ranitidine, Rats. |
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Supervisor |
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prof. Dr. Hala Abd El-Rahman Khattab |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Added Date |
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Monday, April 1, 2019 |
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Researchers
| الاء عياده الحربي | Al Harbi, Alaa Ayadah | Researcher | Master | |
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