Document Details
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Document Type |
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Thesis |
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Document Title |
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Effect of Roselle (Hibiscus sabdariffa L.) against Adriamycin Induced-cardio and Nephrotoxicity in Male Rats تأثير الكركديه ضد السمية القلبية والكلوية المُحدثة بالأدرياميسين في ذكور الجرذان أماني خضر سعيد الليلي |
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Subject |
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Faculty of Home Economics |
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Document Language |
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Arabic |
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Abstract |
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Adrimaycin (ADR) is an antitumor antibiotic drug has been shown to be highly effective in the treatment of cancer and a variety of malignant. However, the successful use of ADR has been hampered by its cardio- and nephrotoxicity, which mediated through oxidative stress. Hibiscus Sabdariffa L.(HS) has shown to possess powerful antioxidant properties. This study aimed to investigate the impact of HS extract (HSE) on ADR-induced cardio- and nephrotoxicity in male rats. The study was conducted on four group of ratss; control, ADR (10 mg/kg b.w), and HSE+ADR groups (500 and 750 mg/kg b.w), where rats received HSE for 1 week before ADR injection. After 3 days from ADR injection, rats were subject to electrocardiography (ECG) analysis, and serum were separation for determination of lactate dehydrogenase (LDH) and creatine kinase (CK-MB), and after 14 days serum were separation for determination of creatinine and urea. Heart and kidneys tissues were subjected for determination of malondialdehyde (MDA) and glutathione peroxidase (GPx) contents, as well as examined microscopically. Results revealed that treatment of rats with ADR increased heart rate, ST height, QT interval and T amplitude, as well as increased LDH, CK-MB, urea and creatinine concentrations and cardiac and renal MDA levels, while it decreased QRS interval and GPx levels. Pretreatment of ADR-treated rats with HSE resulted in a significant improvement in ECG readings and tested heart and kidney enzymes, as well as normalize cardiac and renal contents of MDA and GPx. Histopathological examination of heart and kidney sections revealed that, ADR caused many myocardial and renal injury, while HSE pretreatment showed either mild or slight congestion of myocardial blood and glomerular tuft or no histopathological change. These results suggested that, HSE is effective in ameliorated ADR-induced cardio- and nephrotoxicity in male rats, probably through its active compounds that have antioxidant properties.
Key words: Adrimaycin, Cardiotoxicity, Nephrotoxicity, Hibiscus Sabdariffa L., Antioxidant, Rats. |
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Supervisor |
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Dr. Hala Abd El-Rahman Khattab |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Added Date |
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Tuesday, April 25, 2017 |
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Researchers
| أماني خضر الليلي | Allili, Amani Khadar | Researcher | Master | |
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